News for Healthier Living

Researchers Identify Rare Mutation That Predicts Strong Immunotherapy Response in Colorectal Cancer

A specific subset of POLE gene mutation, called loss-of-proofreading (LOP) mutations, makes colorectal tumors highly responsive to immunotherapy Patients with the specific POLE mutations had long-lasting responses when treated with immunotherapy, whereas those with other POLE mutations did not see similar benefits A new study led by researchers at The University of Texas MD Anderson Cancer Center shows that a specific subset of mutations in the POLE gene is strongly associated with durable responses to immunotherapy in patients with metastatic colorectal cancer (CRC).

November 20, 2025


November 21 2025

November 20 2025

November 19 2025

November 18 2025

November 17 2025

November 16 2025

November 15 2025

November 14 2025

November 13 2025

November 12 2025

November 11 2025

November 10 2025

November 9 2025

November 8 2025

November 7 2025