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News for Healthier Living
Researchers Unlock Safer RNA Therapies for Inflammatory Diseases
Lipid nanoparticles (LNPs) are tiny fat bubbles that are used to deliver medicines, genes, and RNA into cells. However, in some cases LNPs can cause harmful inflammation as a result of the process of RNA delivery. Now, two new solutions can help alleviate inflammation while still getting RNA where it needs to be in the cell. One discovery found that inflammation could be reduced with the addition of a unique biodegradable lipid to the treatment; another solution identified a common drug, called thiodigalactoside (TG), which blocked inflammation when added to the LNP. Today's Nature Nanotechnology features this research from the Perelman School of Medicine at the University of Pennsylvania.
August 11, 2025
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